Colorado Will Begin Accepting Applications for Psilocybin Service Centers on December 31

Dried psilocybin mushrooms.

This development comes as part of the framework established following the 2022 passage of Proposition 122, which legalized regulated psilocybin therapy and the personal use of certain psychedelics for adults aged 21 and older.

Under the program, licenses will be available for businesses involved in psilocybin therapy, cultivation, and testing. The program introduces two categories of therapy providers: standard healing centers and micro-healing centers. Healing centers will be standalone facilities dedicated to psilocybin therapy, while micro-healing centers are designed to integrate these services into existing healthcare practices, such as therapist offices or wellness retreats. This dual licensing system aims to make psilocybin therapy more accessible and affordable, addressing some of the challenges seen in Oregon’s psilocybin program. The state expects to begin issuing licenses as early as March 2025, with some facilities, particularly micro-healing centers, potentially beginning operations shortly after approval. Full-scale healing centers are anticipated to open by late spring or early summer 2025.

Proposition 122, known as the Natural Medicine Health Act, allows those 21 and older to possess psilocybin, psilocin, DMT, ibogaine, and mescaline (excluding peyote). Beyond personal use, the law established a regulated framework for psilocybin-assisted therapies and healing centers, making Colorado the second state in the U.S. to legalize and regulate such treatments, following Oregon’s lead.