The Most Popular Cannabis Strains in the United States As of May 2025

Pineapple Fruz.

Based on the latest data from state regulatory agencies, Leafly rankings, and direct input from readers and retailers, we’ve updated our list of the 10 most popular marijuana strains in the U.S. for May 2025. Three new strains join the lineup this month, with several longtime favorites holding strong and a new #1 leading the pack.

Now topping the list, Lemon Cherry Gelato has become a go-to for its fruity flavor, smooth smoke, and deeply relaxing effects that don’t weigh users down.

With its sharp aroma of floral fuel and fresh ink, this hybrid continues to build momentum, offering a heady high and smooth body relaxation that appeals to experienced consumers.

A tropical-flavored hybrid that’s surged in popularity in 2025, Pineapple Fruz blends pineapple and cream notes with effects that are euphoric, balanced, and perfect for social settings.

This long-reigning favorite continues to draw users with its sweet, vanilla flavor and strong, calming effects that make it a top choice for anxiety and stress relief.

Wedding Cake.

A national staple for years, Blue Dream’s uplifting cerebral buzz and mild body effects keep it a top seller across nearly every legal state.

Kush Mints brings earthy kush flavor with a minty kick. Its smooth, calming effects and balanced hybrid profile have helped it explode in popularity this spring.

With hints of baked apple and a high that’s euphoric without being overwhelming, Apple Fritter remains a favorite for consumers looking to stay functional while relaxing.

Apple Fritter.

Back on the list this month, Runtz is still a dominant strain thanks to its candy-like flavor and consistently strong yet smooth high that blends giggles with full-body calm.

This hybrid is surging in multiple states. Named after the basketball legend, Gary Payton is known for its potency, earthy flavor, and ability to lift moods while keeping users grounded.

Gelato wraps up the list with its signature creamy, dessert-forward flavor and a mellow, euphoric high that makes it ideal for winding down at the end of the day.