The 25 Most Popular Marijuana Strains in the First Half of 2025

Based on sales data, online traffic, and retailer feedback from multiple adult-use states, the following strains stood out for their popularity, consistency, and unique effects.

A potent cross of Biscotti and Jealousy, Permanent Marker delivers a heavy-hitting experience that leans sedative. Its intense, inky aroma and colorful trichomes have made it one of the most eye-catching and talked-about strains of 2025.

This visually stunning strain continues to dominate shelves with its vibrant purple hues and fruity, soap-like scent. A hybrid with a quick onset, Zoap brings an uplifting head high before gently tapering into relaxation.

Short for Rainbow Sherbert #11, RS11 maintains strong consumer demand thanks to its candy-sweet flavor and mood-boosting effects. Its ability to keep users engaged and talkative has made it a social favorite.

White Truffle’s savory funk and calming nature continue to win over consumers. Its relaxing yet clear-headed qualities make it one of the more functional indicas available today.

This fruity powerhouse remains one of the top-selling strains of the year, especially on the West Coast. Its sweet citrus flavor pairs with euphoric effects that are uplifting without being racy.

Despite increased competition, Cereal Milk holds strong with its creamy vanilla taste and long-lasting hybrid buzz. Popular among novice and experienced users alike, it provides a happy medium between energy and calm.

Named after the NBA legend, this Cookies x Snowman cross continues to be a staple across dispensaries. With strong THC content and a peppery, earthy flavor, Gary Payton appeals to consumers looking for a punchy high that hits fast.

This strain stands out with its savory garlic and skunky funk, paired with powerful sedating effects. It’s grown in popularity as a nighttime option for seasoned users seeking heavy relaxation.

Baking-inspired and bursting with sweet, doughy flavor, Georgia Pie has seen steady demand thanks to its rich taste and mellowing body high. It’s been especially popular in newer recreational markets.

Also known as Miracle Alien Cookies #1, this strain remains relevant in 2025 for its gassy citrus profile and euphoric, floaty effects. It continues to impress with its dense buds and layered terpene profile.

These strains reflect not only the diverse tastes of marijuana consumers today but also the growing influence of unique flavors, terpene complexity, and well-balanced effects in shaping market demand.

Despite being a longtime favorite, Zkittlez remains among the best-selling strains this year. Its tropical fruit profile and mellow, happy high make it a consistent hit, particularly in regions that favor flavorful hybrids.

Still a major player in 2025, Runtz has remained in the top ranks due to its candy-like sweetness and high THC content. Crosses and offshoots abound, but the original Runtz continues to anchor menus across the country.

This indica-leaning hybrid has been especially popular in Midwest and Mountain states in 2025. Known for its grape and diesel flavor and calming effects, Garanimals is often sought out for nighttime use or deep stress relief.

A fan favorite for its dessert-like flavor and ultra-smooth smoke, Ice Cream Cake remains in high demand this year. It delivers strong body effects with a mentally soothing overlay that appeals to medical and adult-use markets alike.

With its orange rind and cherry funk aroma, Super Boof has quickly become a standout in 2025. Users describe it as a strong, uplifting strain that doesn’t cloud focus, making it a hit for productive afternoons.

A flavorful powerhouse, London Pound Cake continues to thrive in 2025 for its dessert-inspired aroma and deeply relaxing high. Its sweet berry and citrus profile, paired with its heavy indica effects, makes it a favorite for winding down.

This strain has picked up steam in 2025 due to its complex mix of grape, fuel, and chem notes. Grape Gas delivers a potent, euphoric onset that settles into a calm and creative buzz, appealing to both day and night users.

With its dark purple buds and rich cherry flavor, Black Cherry Gelato stands out on the shelf and in effect. Consumers praise its mood-boosting, mellow high that eases anxiety without knocking them out.

A cross that surged in the first half of 2025, Banana Cream Jealousy combines a creamy banana flavor with strong, euphoric body effects. Its potency and smooth smoke have helped it become a regular on top-seller lists.

This strain’s unique flavor—reminiscent of chocolate cookies and campfire s’mores—has kept it hot in 2025. Its dense frost-covered buds and long-lasting body high make it ideal for seasoned users seeking deep relaxation.

Trop Cherry has gained national traction this year for its tropical fruit flavor with a tart cherry punch. The hybrid effects lean balanced, providing an initial burst of energy followed by a chill, social vibe.

Associated with rapper Wiz Khalifa, this strain is known for its cool mint aroma and strong hybrid effects. In 2025, it’s remained a bestseller thanks to its appeal across a wide range of consumers, from fans to serious smokers.

This newer cross of Gary Payton with a fruity phenotype exploded in 2025, offering a sweet strawberry taste and a strong, euphoric head high. It’s been especially popular in legal markets that value boutique genetics.

Gello has quietly climbed the charts this year with its jiggly name, gelato-like flavor, and relaxing but functional high. It’s often recommended for winding down after work without sacrificing clarity.

A consistent performer, Biscotti stays popular in 2025 thanks to its smooth smoke, nutty-sweet flavor, and heavy, couch-locking high. It remains a staple among indica lovers looking for something reliable and flavorful.