Study: Novel Nanomicelle Delivery System Greatly Enhances CBD Absorption, Stability, and Solubility

The researchers created the nanomicelles by combining γ-polyglutamic acid as the hydrophilic component with cholesterol as the hydrophobic material. The resulting CBD-loaded nanomicelles demonstrated key advantages: an average particle size of 163.1 nanometers, strong encapsulation efficiency of over 84%, and stability at both room and body temperatures. Notably, the apparent solubility of CBD increased 424-fold compared to free CBD. The formulation also showed pH-sensitive release, meaning it could adapt to varying conditions in the gastrointestinal tract. In cell culture experiments, the nanomicelles proved biocompatible and significantly improved CBD uptake and transport across intestinal cells.

In animal testing, orally administered nanomicelles resulted in higher peak plasma concentrations and overall systemic exposure than free CBD, while also lowering clearance rates.

The findings suggest that this delivery platform could help unlock CBD’s full therapeutic potential by improving its bioavailability and stability. According to the authors, the γ-PGA-g-CHOL nanomicelles represent a promising oral delivery system that could enhance CBD’s clinical effectiveness across its antiepileptic, anticonvulsant, and anticancer applications.