The Most Popular Cannabis Strains in the United States as of November 2025
Wedding Cake.
Based on nationwide sales data provided by state regulatory agencies, the research firm Headset, and the strain review site Leafly, here are the top strains dominating menus across the United States this November.
A longtime favorite, especially for evening use, Wedding Cake continues to attract those seeking calm and relief from stress. Its sweet, vanilla-frosted aroma and subtle pepper notes define its signature flavor, while its relaxing hybrid effects make it ideal for unwinding at the end of the day.
Permanent Marker has developed a loyal following for its strong aroma, dense buds, and long-lasting calm. Its hybrid effects lean heavily toward relaxation and introspection, making it a dependable pick for quiet nights or winding down after work.
Lemon Cherry Gelato remains one of the most versatile and visually striking strains available. Its combination of citrus and berry flavors, balanced hybrid profile, and even-keeled high appeal to both social and solo consumers, keeping it consistently among the nation’s top sellers.
A reliable hybrid, Blue Dream maintains its popularity thanks to its balanced high and approachable flavor. Known for its smooth berry sweetness, it delivers a steady mix of mild euphoria and calm focus, suitable for both daytime creativity and relaxed evenings.
Rising in popularity through late 2025, Moon Fog’s frosty purple appearance and dreamy effects have quickly made it a dispensary staple. It’s an indica-dominant strain that combines gentle euphoria with body relaxation, suited for evening use.
Zoap’s pastel buds and candy-like scent make it visually and aromatically appealing, but its balanced high keeps it from being a novelty. It offers a smooth and clear experience that suits both recreational use and functional relaxation.
Tangie continues to stand out for its unmistakable tangerine aroma and uplifting sativa effects. It’s widely used during mornings and active hours, providing a clean, energetic high that enhances focus without overwhelming.
Known for its potency and flavor complexity, Gary Payton combines earthy, spicy, and gas-like notes with a strong yet controlled high. It remains a favorite for experienced users who want intensity and clarity in equal measure.
RS11 maintains momentum thanks to its candy-sweet terpene profile and balanced euphoric effects. Its mellow and social high makes it a frequent choice for relaxed evenings or friendly gatherings.
Super Runtz builds on the Runtz legacy with amplified aroma, flavor, and potency. Its striking buds and rich terpene mix have helped it gain mainstream popularity, delivering a potent yet balanced hybrid experience.
(Photo credit: Ginja.club).
A newer entrant in the market, Blackberry Caviar blends rich berry and grape flavors with subtle citrus and gas notes. The indica-leaning strain offers a smooth body high and calming head effect, ideal for slow-paced autumn nights.
Apple Fritter closes the list as a dependable hybrid that balances creativity and calm. Its dessert-like sweetness and mild effects make it a popular option for users seeking relaxation without sedation.