Study: CBD Shows Potent Antibacterial Activity Against Drug-Resistant Enterococcus Strains

cannabis oil extracts – healthcare

In a new lab study published in Molecules, researchers say cannabidiol (CBD) may have strong antibacterial effects against Enterococcus bacteria, including strains that are increasingly difficult to treat with existing antibiotics. The research was conducted by scientists from Nicolaus Copernicus University and the Wrocław University of Environmental and Life Sciences, who examined whether commercially available CBD products could inhibit the growth of Enterococcus faecalis and Enterococcus faecium. These Gram-positive bacteria are common in the environment and the normal human microbiota, but they are also a major cause of hospital-acquired infections and are known for their ability to resist multiple antibiotics.

Researchers tested five CBD oil products containing cannabidiol or related derivatives, along with a nearly pure 99% CBD crystal product. The antimicrobial effects were evaluated against 20 clinical strains of Enterococcus using a standard microdilution method to determine minimal inhibitory concentrations, or MICs, which measure the lowest concentration needed to stop bacterial growth.

Across all tested strains, CBD demonstrated clear antibacterial activity, with MIC values at or below 1 microgram per milliliter. The researchers found that higher concentrations of CBD consistently produced stronger antibacterial effects. Notably, pure CBD and CBD crystals were more effective against E. faecium than E. faecalis, a difference that was statistically significant.

Given the growing spread of multidrug-resistant Enterococcus strains in healthcare settings, the findings point to CBD as a potential candidate for future antimicrobial development. While the authors emphasize that additional research is needed, including studies to better understand how CBD disrupts bacterial survival, they conclude that their results provide a strong foundation for exploring CBD-based approaches as possible new tools in the fight against antibiotic-resistant infections.

The study was conducted by researchers at the University of Virginia, and made aware of it.