Cannabis Root Nanoparticles Show Promise in Protecting Skin Cells From UVB Damage
- The study found that nanoparticles derived from Cannabis sativa root cultures (CA-NPs) may protect skin cells from UVB-induced damage and inflammation.
- CA-NPs improved viability, reduced apoptosis, and lowered oxidative stress in human keratinocyte cells after UVB exposure.
- They suppressed MMP enzymes linked to skin aging while increasing the expression of skin barrier-related genes, suggesting enhanced skin protection.
- The research indicates potential for CA-NPs as natural skincare ingredients, though further studies are needed to confirm effects in humans.
A new study published in the International Journal of Cosmetic Science found that nanoparticles derived from Cannabis sativa root cultures may help protect skin cells from UVB-related damage.
Researchers from the Korea Research Institute of Bioscience and Biotechnology examined extracellular vesicle-like nanoparticles isolated from cannabis adventitious root cultures, referred to as CA-NPs. The study focused on their potential use in cosmetics and skin-care applications, particularly for preventing photoaging and inflammation caused by UVB exposure.
Using human keratinocyte cells, researchers found that the cannabis-derived nanoparticles improved cell viability, reduced apoptosis and lowered oxidative stress after UVB exposure. The nanoparticles were also found to suppress the expression of MMP-1, MMP-3 and MMP-9, enzymes associated with skin aging and tissue breakdown.
At the same time, CA-NPs increased the expression of several skin barrier-related genes, including HAS1, FLG, LOR and IVL. Researchers also found that the nanoparticles influenced MAPK and Nrf2 signaling pathways, suggesting they may reduce inflammation while strengthening antioxidant defenses.
The particles were approximately 128 nanometers in size and showed strong physicochemical stability, according to the study.
Researchers concluded that Cannabis sativa-derived CA-NPs “offer a promising natural approach” for protecting the skin from UVB-induced damage, supporting their potential as bioactive candidates for future skincare or cosmeceutical products.
The findings are early-stage and based on cell culture research, meaning additional studies would be needed before determining whether the same effects occur in human skin or finished consumer products.